From muscle contraction to tumour control Exercise as an immunometabolic and supportive therapy in oncology

Main Article Content

Ivana Grle
Maki Grle
Jerko Prlić
Dejan Tiric
Bozenka Galic Tiric
Jasmin Budimlić
Nijaz Skender
Mate Vukoja
Boriss Bazanov
Ivica Franjko
Ahmet Naci Dilek
Ivan Đuroci
Besnik Morina
Davor Ljesević
Goran Sporis
Patricia Zupanc
Adem Preljević
Goran Špaleta
Ernest Šabić

Abstract

Exercise is increasingly positioned as an adjunct to oncology care, yet its clinical benefits and proposed antitumour mechanisms are often discussed in parallel rather than as a unified biological model. This focused mini review integrates 20 unique full-text sources spanning meta-analyses, systematic and narrative reviews, consensus guidance, and translational studies. The evidence supports a multiscale framework in which muscle contraction generates acute neuroendocrine and myokine signals, improves tumour perfusion and oxygenation, alters metabolite competition within the tumour microenvironment, mobilises cytotoxic immune cells, and preserves host muscle and functional reserve. Clinical evidence is strongest for improvements in cardiorespiratory fitness, strength, fatigue, physical function, and quality of life, whereas direct tumour control and enhancement of immunotherapy remain supported mainly by preclinical and early human mechanistic data. Important tensions include the context-dependent biology of interleukin-6, the distinction between vascular normalisation and tumour-promoting angiogenesis, the uncertain optimal exercise dose, and the risk that excessive energy expenditure may be inappropriate in severe cachexia. We propose a precision exercise oncology model that matches modality and dose to tumour phenotype, treatment phase, symptoms, physiological reserve, and dynamic monitoring. Exercise should be treated as evidence-based supportive care with plausible disease-modifying potential, not as a substitute for anticancer therapy.

Article Details

How to Cite
Grle, I., Grle, M., Prlić, J., Tiric, D., Tiric, B. G., Budimlić, J., … Šabić, E. (2026). From muscle contraction to tumour control: Exercise as an immunometabolic and supportive therapy in oncology. Physical Activity, Exercise and Cancer, 3(2), 115–128. https://doi.org/10.55860/MWXE3541
Section
Review Paper
Author Biographies

Ivana Grle, University Clinical Hospital Mostar

Department of Physical Medicine and Rehabilitation.

Maki Grle, University Clinical Hospital Mostar

Department of Orthopaedics.

Jerko Prlić, University Clinical Hospital Mostar

Department of Orthopaedics.

Dejan Tiric, University Clinical Hospital Mostar

Department of Obstetrics and Gynecology.

Bozenka Galic Tiric, University of Mostar

Chair of Occupational Medicine. Faculty of Medicine.

Jasmin Budimlić, University of Bihać

Deparment of Physical Education and Sport. Faculty of Pedagogy.

Nijaz Skender, University of Bihać

Deparment of Physical Education and Sport. Faculty of Pedagogy.

Ivica Franjko, University of Osijek

Faculty of Kinesiology Osijek.

Ahmet Naci Dilek, Bartin University

Faculty of Sport Science.

Ivan Đuroci, University of Zagreb

Faculty of Kinesiology.

Besnik Morina, University of Priština - Kosovska Mitrovica

Faculty of Physical Education and Sport.

Davor Ljesević, University of Zagreb

Faculty of Kinesiology.

Goran Sporis, University of Zagreb

Faculty of Kinesiology.

Patricia Zupanc, University of Zagreb

Faculty of Kinesiology.

Ernest Šabić, University of Bihać

Faculty of Pedagogy.

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